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For example, melatonin supplementation has been found to increase the expression of genes such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), and pentraxin 3 (PTX3) (77)
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Mice were housed in a temperature-controlled room with a 12-h light/dark cycle, 40%60% humidity, and ad libitum access to water and food
Local application at the swollen brain implies a direct effect
doi: 10.1089/ars.2007.1628 33 SemenzaGL
