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Description
Mammalian target of rapamycin (mTOR), along with other proteins and intracellular signaling pathways such as PPAR-gamma coactivator 1-alpha (PGC-1), sirtuins, nuclear respiratory factor 1 (NRF1), AMPK, mitochondrial transcription factor A (TFAM), and PTEN-induced kinase 1(PINK)/E3 ubiquitin ligase (PARKIN) are involved in the mitochondrial quality control, which in turn depends on the coordination between mitochondrial biogenesis, mitochondrial dynamism, and mitophagy (Vives-Bauza et al., 2010
PMID: 21508395

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