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Research demonstrates that TB-500 forms functional complexes with PINCH-1 and integrin-linked kinase (ILK) that can inhibit TNF--induced NF-B activation through blocking RelA/p65 translocation, providing rapid suppression of inflammatory transcriptional programs

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Joffe RT, Bagby RM, Levitt A

doi: 10.1212/WNL.43.2.301
