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HCQ acts by inhibiting eTLR activation, reducing ERK signaling, dampening immune cell activity and decreasing intralysosomal protein processing 55

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The progressive form of AD can be caused by cerebral disorders, intoxication, infection, and defects in the pulmonary and circulatory systems, leading to reduced oxygen supply to the brain, by nutrient and vitamin B12 deficiency, as well as by tumors [5, 6, 7, 8]

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therefore, their levels are not suitable as a marker

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