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The NRF2-dependent effect was identified through the antioxidative response element in target gene loci, while NRF2-independent effects act through DNA 5hmC modifications via the regulation of the metabolite L2HG

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Anyone pregnant, breastfeeding, or with a diagnosed metabolic, hepatic, or endocrine condition falls entirely outside any studied context and should not be a subject of self-directed use

Source: Lang, C

Topical Therapeutic Products If a product claims therapeutic benefits, such as wound repair, dermatitis treatment, or improvement of pathological skin damage, it must follow the OTC drug application pathway

Subsequently, the THC solution was diluted in physiological saline to a final concentration of 2.6 mg/ml and 5% Cremophor