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10.4081/ejtm.2022.10416 13 FalckenhaynC.BienkowskaA.ShleJ.WegnerK.RaddatzG.KristofB.et al (2024)

The range of these signaling pathways is constantly updated and expanded upon, and they may have complex intersections and interactions

Insulin resistance in rheumatoid arthritis: Disease-related indicators and associations with the presence and progression of subclinical atherosclerosis

it influences gut motility (helping to keep things moving regularly), can positively shift the composition of your gut microbiome (favoring beneficial bacteria), and helps reduce overall inflammation

These molecules activate and recruit immune cells (M1 macrophages, neutrophils, Th17 cells), which in turn exacerbate oxidative stress and iron dysregulation, creating a self-amplifying cycle