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Septic shock A systemic response to severe bacterial infections or Gram-negative bacterial endotoxins (such as LPS) that leads to a hyperactive and dysregulated network of inflammatory cytokines, affecting vascular permeability, cardiac function and metabolic balance, which leads to tissue necrosis, multiple-organ failure and death

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Roehnelt explains how insulin functions in the body, what happens when insulin resistance develops, and why chronically elevated insulin drives inflammation, weight gain, metabolic dysfunction, and disease progression

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