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Given its intimate association with ROS, cell death can be triggered by genetically programmed mechanisms (such as apoptosis, necrosis, and pyroptosis), metabolic dysfunction, including ferroptosis, cuproptosis, oxytosis, disulfidptosis [6] and the recently identified sodium-dependent cell death [7]

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4-hydroxy-2-nonenal (4HNE), a major product of lipid peroxidation, increased in aged human retina [39] and induces an AMD phenotype-like in RPE cells [40]

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Some human studies show reduced muscle damage markers with taurine supplementation

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These limitations limit its in vivo efficacy, and represent a key challenge in further transformation research against hepatorenal metabolic barrier damage

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Interest in taurine surged following the discovery in 1975 that cats fed diets containing little or no taurine suffered retinal degeneration accompanied by low retinal and plasma taurine concentrations (5)

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doi: 10.1093/oxfordjournals.molbev.a026334 10 ChenC.ChenH.ZhangY.ThomasH

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