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Given its intimate association with ROS, cell death can be triggered by genetically programmed mechanisms (such as apoptosis, necrosis, and pyroptosis), metabolic dysfunction, including ferroptosis, cuproptosis, oxytosis, disulfidptosis [6] and the recently identified sodium-dependent cell death [7]

4-hydroxy-2-nonenal (4HNE), a major product of lipid peroxidation, increased in aged human retina [39] and induces an AMD phenotype-like in RPE cells [40]
Some human studies show reduced muscle damage markers with taurine supplementation

These limitations limit its in vivo efficacy, and represent a key challenge in further transformation research against hepatorenal metabolic barrier damage
Interest in taurine surged following the discovery in 1975 that cats fed diets containing little or no taurine suffered retinal degeneration accompanied by low retinal and plasma taurine concentrations (5)
doi: 10.1093/oxfordjournals.molbev.a026334 10 ChenC.ChenH.ZhangY.ThomasH
