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Each year, ~70 million individuals worldwide sustain a TBI, which is a leading cause of injury-related death and disability (Dewan et al, 2019)

However, not all patients are candidates for this approach

Myocardial ischemia can trigger NLRP3 inflammasome to activate caspase-1

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This finding provides some reassurance, though animal data never guarantees human safety

Some parameters change quickly while others need weeks
