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Mechanistically, ADO directly binds AHCY, inducing a conformational change that favors the formation of an enzymatically inactive dimer

Phosphofructokinase is also under tight regulation via other substrates including ATP hence, increased FA oxidation exerts its inhibitory effect by also augmenting ATP-mediated inhibition.16 Thus, accumulation of FA metabolic products directly reduces glycolytic flux

9 , eade5041 (2023)

To do this: Sit, extend one leg, and reach forward gently

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Castegna A, Thongboonkerd V, Klein JB, Lynn B, Markesbery WR, Butterfield DA