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Thus, it is possible that OPDA was still produced also during R, but the total amount decreased due to its conversion to JA (Figure 6)

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Regardless, lipedema patients at risk of lymphedema have an additional incentive to prevent chronic swelling from taking hold

However, these findings should be regarded as hypothesis-generating and require validation through targeted in vitro functional assays, transcriptomic analyses, and in vivo studies to establish bioavailability, efficacy, and safety under physiological conditions

doi: 10.1038/ncomms3760
