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The affected nerves can cause pain and involuntary contractions in nearby muscles

Access this article Similar content being viewed by others References Sundd P, Gladwin MT, Novelli EM (2019) Pathophysiology of sickle cell disease

125 IFN- and TNF promote the inducible nitric oxide synthase (iNos) gene promoters response to NF-B through activation of JAK-STAT signaling in muscle fibroblasts recruitment, thereby activating the iNOS/nitric oxide (NO) pathway and inducing muscle atrophy

Metformin reduces endothelial injury by increasing insulin sensitivity and scavenging free radicals [164] , while TZDs such as rosiglitazone activate the PPAR- pathway, exert anti-inflammatory effects, and improve vascular responsiveness [165]