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This increase in cytokine production further increases oxidative stress which in turn affects mitochondrial functioning and disrupts the production of ATP

Preclinical studies revealed that roxadustat-treated GBM cells exhibit significantly increased lipid peroxidation and intracellular iron accumulation

[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Rattanaumpawan P., Ussavasodhi P., Kiratisin P., Aswapokee N

Funding CWI is supported by the Interdisciplinary Center for Clinical Research (IZKF) at the University of Wrzburg (A-303 to CWI, A-421 to CWI and JWi, N-362 to CWI), by the Deutsche Stiftung Neurologie and the ParkinsonFonds Germany and by the University Research Funds of the State of Bavaria

Nitric oxide synthase regulates vascular tone, and tissue hypoxia during ischemia impacts both endothelial cells and smooth muscle cells, contributing to vascular dysfunction