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Frontiers in Pharmacology, 11 , Article 608518

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Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes

If symptoms persist beyond two weeks, worsen, or come with chest pain, facial droop, slurred speech, or severe weakness, seek urgent care