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On re-exposure, the drug-protein conjugate cross-links its IgE which bound to the high-affinity receptor and induces the degranulation of mast cells and basophils, and release of inflammatory mediators that induce urticaria, vasodilatation, increased vascular permeability, edema and bronchoconstriction, leading to cardiovascular failure, bronchospasm and even death 2,10

H., Olanow, C

84:806-810 [PubMed: 2813591] 175

The association between serum Sestrin2 and the risk of coronary heart disease in patients with type 2 diabetes mellitus
