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Benson KF, Ager DM, Landes B, et al

Scientific Reports, 10(1), 8484

Compound 89 can be reacted with tert-butyl bromoacetate via a Suzuki cross-coupling reaction and, after ester hydrolysis, yields a carboxylic acid lenalidomide derivative (90) that can be attached to amine-containing linkers, leading to compound 91 147

In addition to IGF pathways, anti-tumor effects on PI3K/AKT/mTOR and MAPK/ERK pathways with metformin exposure were observed, leading to the upregulation of markers of cell cycle arrest, apoptosis, and autophagy and downregulation of markers associated with senescence and the inhibition of cell migration (Hanna et al., 2012