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Eur J Neurol 2024;31(7):e16283

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During ferroptosis, heme oxygenase 1 (Hmox1) is up-regulated with increased free iron release from cardiomyocytes, and then left ventricular remodeling would be triggered, causing severely impaired function of left ventricular in MI patients (Song et al., 2021) (Figure 1)
Following a 48-h incubation, the cells were lysed to facilitate the extraction of proteins for subsequent western blot analysis

There are also a variety of drug-specific challenges including variable penetration, changes in the size, charge, hydrophobicity and requirement for the dose optimization can complicate the strategy of therapy

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