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Are free radicals involved in thiol-based redox signaling

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Ferroptosis is regulated by GPX4 and SLC7 A11 and has recently been recognized as a potential treatment target in drug-resistant cancer, especially in NSCLC (Chen et al

Importantly, in the patients bearing tumors with NRF2-KEAP1 alteration a significantly increase in expression of NRF2 target genes was observed, such as NQO1, and the enzymes responsible for GSH synthesis, GCLC and GCLM, which indicates that GSH levels are also higher (Fig

Therapy resistance: modulating evolutionarily conserved heat shock protein machinery in cancer

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