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Glutamine is also second only to glucose in terms of persistent interest in its role in tumor cell metabolism, which now dates back more than 50 years (Eagle, 1955

Effects of exercise training on insulin-regulatable glucose-transporter protein levels in rat skeletal muscle

6b) of silymarin NCs indicated a mean size of approximately 23.14 nm

For example, it has been reported that CD8 + T cells have facilitated tumor ferroptosis by releasing IFN-, which disrupts the cystine uptake by tumor cells, triggers lipid peroxidation accumulation, and ultimately results in ferroptotic tumor cell death ( + T cells are more sensitive to ferroptosis inducers RSL3 than B16 and MC38 cancer cells ( + T cells underwent lipid peroxidation in lipid laden TME and became dysfunctional (179), targeting lipid peroxidation to enhance cancer therapy must consider the complex nature of TME

CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy

doi: 10.7554/eLife.61965 171 DUrsoABricknerJH
