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Renal Elimination: Altering urine pH, while maintaining normal urine flow, can be effective in increasing the renal elimination of drugs that are weak electrolytes

591,592 Interestingly, the pathological shift arises not from loss of native function but from a toxic gain of function through aggregation, illustrating that even minor perturbations in protein stability can drive systemic disease

Stern RH
Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB II, et al

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The GNAT family of acetyltransferases is present in both eukaryotes and prokaryotes (Table 1) (Wang et al., 2022
