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Administration of LPS in a mouse model of septic shock decreased the survival rate to 20%

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Trichloroethylene exposure results in the phosphorylation of histone H2AX in a human hepatic cell line through cytochrome P450 2E1mediated oxidative stress

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Supportive therapy such as inhaled beta 2 -agonists (for patients experiencing bronchospasm) and antihistamines (for control of cutaneous symptoms) can also be helpful, but should never replace epinephrine as first-line therapy