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Compliance with Ethics Guidelines The study was designed, conducted, and monitored in accordance with the World Medical Association Declaration of Helsinki (1989) and International Council for Harmonisation guidelines

While the impact of OTA appears to be related to its concentration in the kidney, sufficiently high levels of OTA will cause oxidant damage in any organ tissue [79]

and Stec DE (2018) Bilirubin, a Cardiometabolic Signaling Molecule

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This observation has been reported in earlier studies in obese and hyperinsulinemic subjects, and in patients with Cushings syndrome, in whom hepatic sensitivity to GH is increased when compared to lean subjects (95, 103)

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