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Alcohol consumption-related cell death processes and DAMP secretion Chronic alcohol exposure induces multiple forms of cellular stress, including oxidative stress, hypoxia, failed protein folding, and ER stress, resulting in the activation of both intrinsic and extrinsic pathways of apoptosis [113,114,115]
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Additionally, 13 C MRS studies of neurosurgical specimens have revealed marked impairment in Glu/Gln cycling compared with more histologically normal tissue (13)

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We also confirmed the delayed formation of the thiomethyl metabolites compared to conventional APAP metabolites, likely related to delayed reabsorption into the systemic circulation after the enterohepatic circulation

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