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Cancer cells also need to keep ROS production under control, and glutamine converted in glutamate serves the synthesis of glutathione peroxidase as a major anti-oxidative enzyme from glutamine

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Reducing iron toxicity accumulation and mitochondrial dysfunction through CISD1 gene inhibition enhances the process of erastin-induced iron ptosis, which does not involve GPx4 [43]

132 MAT2A overexpression improves the activity of the V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog G (MAFG) promoter

*Correspondence: Eva Duborsk, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers