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Case 2 was different because the patient had been injected with Vit B12 supplements in some other center where he was admitted for complaints of extreme weakness and anemia

[DOI] [PMC free article] [PubMed] [Google Scholar] Malekzadeh M

In contrast to long-chain, n-6 polyunsaturated fatty acids (n-6 PUFAs), which support inflammatory processes, omega-3 are anti-inflammatory molecules and thus they are fundamental for keeping inflammation under control [101]

Common causes of exogenous pigmentation are henna, colored nail lacquer, nicotine, dirt, and potassium permanganate.[1] Reversible melanonychia has been reported with vitamin-B12 deficiency, especially in dark-skinned individuals.[2] Reduced glutathione levels in B12 deficiency causes disinhibition of tyrosinase, the major enzyme involved in melanogenesis.[3] Strict vegetarian diet, knuckle pigmentation, low serum vitamin-B12 levels, and a raised serum homocysteine along with raised methylmalonic acid levels (c.f