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5.2 Therapeutic strategies that indirectly affect SUA-related pathological processes through metabolic regulation In addition to directly reducing uric acid levels, metabolic abnormalities may indirectly influence the onset and progression of gout by altering uric acid production, excretion, and susceptibility to inflammation

TNF- promotes chronic inflammation that drives muscle pain and fatigue [37,38,39,40]

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PLoS Genet 8, e1002446 Brukhin V, Albertini E (2021) Epigenetic modifications in plant development and reproduction

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That regulatory status is important for patients to understand, but it should be separated from the biological research