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Thus, two animal studies report that T may induce hepatic P-gp expression when injected intraperitoneally or subcutaneously in high doses, which are unusual routes of administration and as such of limited relevance in a nutritional context

Comorbidities were selected based on their known relevance for cognition in patients with dementia and included diabetes mellitus, arrythmia, heart failure, atrial fibrillation, alcohol-related disease, chronic kidney disease, cardiovascular disease, ischemic heart disease, respiratory disease, stroke, anaemia, liver disease, malignancy and obesity (Appendix)

Wei S, Qiu T, Yao X

Cell Physiol Biochem 44(6):20912104 Kim S, Indu Viswanath AN, Park JH, Lee HE, Park AY, Choi JW et al (2020May) Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinsons disease animal model

Additionally, glutathione reductase (GR) supports this antioxidant system by sustaining the glutathione (GSH) cycle and regeneration, thus enhancing the serums capacity for ROS detoxification 3

[DOI] [PMC free article] [PubMed] [Google Scholar] 194.Filali-Mouncef Y, Hunter C, Roccio F, Zagkou S, Dupont N, Primard C, et al