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High doses of IL-2 promote the maturation and proliferation of effector and memory T cells, whereas lower doses support the development, longevity, and functionality of regulatory T (Treg) cells, a subset of CD4 + T cells crucial for maintaining immune balance and tolerance

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The downregulation of Bcl-2 is implicated in curcumin-induced apoptosis and cell cycle arrest in G2/M phase

Axitinib reduced the destruction of tight junction proteins and reduced BBB permeability in mice, while increasing spatial awareness, exploration, associative memory, working memory, and lowering -amyloid levels (Yuan, et al

Insulin signaling pathways in obesity and metabolic disease Metabolic tissues develop lipid intermediates alongside altered adipokine expression profiles and compromised mitochondrial function, progressively attenuating insulin responsiveness (64, 65)

doi: 10.1007/s11104-012-1574-z 33 GuoW