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rs6276, rs6277, and rs1800497) in the DRD2 gene are associated with decreased D 2 R expression and function attributable to decreased D 2 R messenger RNA stability and synthesis of the receptor and are associated with elevated blood pressure and hypertension [10, 39]

A comprehensive review of the vascular consequences of diabetes in the lower extremities: current approaches to management and evaluation of clinical outcomes

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This is why many experienced lifters intentionally stay in the 4-8mg range rather than pushing to maximum doses