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Subsequently, colorectal cancer cells release TGF-1 into the tumor microenvironment, where it activates the mothers against decapentaplegic homolog 3 (SMAD3) pathway in memory CD8 + T cells, ultimately impairing their antitumor activity ( LSS is downregulated in tumor cells, leading to intracellular accumulation of 2,3-oxidosqualene

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doi:10.1007/s11626-012-9543-7

Free T4 and T3: free T4 is typically low in hypothyroidism and elevated in hyperthyroidism