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In this context, combining targeted ammonia metabolism intervention (e.g., using the GLS1 inhibitor CB-839) with CAR-T cell infusion not only blocks tumor cell utilization of ammonia but also enhances T cell adaptability through metabolic plasticity, thereby simultaneously alleviating the immunosuppressive microenvironment and prolonging CAR-T cell persistence (156, 159)

Additionally, tolizumab has demonstrated therapeutic efficacy in managing systemic juvenile idiopathic arthritis, adult Stills disease, and Crohns disease (251)

Cell Type and Brain RegionResolved Mouse Brain Proteome. Nature Neuroscience 18: 18191831

Phase I dose-escalation trial of Sym004, an anti-EGFR antibody mixture, in Japanese patients with advanced solid tumors

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Development and verification of an endogenous PBPK model to inform hydrocortisone replacement dosing in children and adults with cortisol deficiency