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T cell receptor engagement induces Ca 2+ release, which in turn augments mitochondrial functional roles including the tricarboxylic acid (TCA) cycle and ROS generation [74]

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Although scRNA-seq and snATAC-seq datasets of pancreatic -cells have not yet been directly integrated with gut microbiome metagenomic or metabolomic profiles within a single unified study, the parallel development of these fields highlights potential points of convergence between -cell transcriptional states and microbiota-derived metabolites (Son et al., 2020)

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But diagnosing at this stage can help tighten up diabetes control, blood pressure control and lipid control and prevent further progression of the disease