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212,213 The pathophysiological mechanism of GLP-1 in metabolic diseases GLP-1 plays a crucial role in the pathophysiology of metabolic diseases, particularly in T2DM and obesity

In addition, neuroinflammation in SUD can also be induced by the activation of toll-like receptor 4 receptors and NLRP3 inflammasome (141143)

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Regulation of mitogen-activated protein kinase signaling pathways by the ubiquitin-proteasome system and its pharmacological potential

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Parkin Parkin is a cytosolic protein that functions as a ubiquitin E3 ligase to ubiquitinate target proteins and modulate many cellular processes to protect dopaminergic neurons [133]