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Arch Fam Med 3(2):193-5
United States Patent US8268372 (B2) Orumets K, Kevvai K, Nisamedtinov I, Tamm T, Paalme T (2012) YAP1 over-expression in Saccharomyces cerevisiae enhances glutathione accumulation at its biosynthesis and substrate availability levels

One of the historical challenges with glutathione is that the standard "plain" capsule form is often broken down by enzymes in the stomach and digestive tract before it can ever reach the bloodstream

J Mol Cell Cardiol

Similar to their mammalian homologue, these enzymes specifically degrade intracellular GSH while yielding 5-oxoproline and cysteinylglycine (Paulose et al., 2013)

Refrigeration may help preserve the potency of GSH