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[12] Other transgenic models have used other reporter genes such as enhanced green fluorescent protein (EGFP), tdTomato or luc to visualize senescent cell burden in vivo , as characterized by high expression levels of p16 or p21

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Increased expression of UCP3 is associated with increased oxygen use and reduced cardiac efficiency in dietary models of obesity.48 The detrimental processes activated by mitochondrial dysfunction occur in addition to damage by lipotoxic products from the accumulation of triglycerides