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LKB1 deletion promotes the expression of hypoxia-inducible factor (HIF)-1 and stabilizes it by regulating mTOR activity in NSCLC cells

This, in turn, can restrict or competitively inhibit SSADH activity, indirectly influencing GABA metabolism (Kilian et al

This led us to hypothesize that AML cells initiate the de novo serine biosynthesis pathway in response to crisantaspase treatment and that inhibiting this pathway in combination with crisantaspase would enhance AML cell death

Therapeutic potential of Vagus nerve stimulation for inflammatory bowel diseases

Most patients experience peak GI symptoms during the first 2-4 weeks of treatment or immediately after dose increases

The absence of human teratogenicity data means risk cannot be quantified, but early first-trimester exposure coincides with organogenesis when developmental signaling is most vulnerable to external modulators