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Description
PD is characterised by a progressive loss of, primarily, dopaminergic neurons of the substantia nigra that project to the striatum, resulting in its motor symptoms of bradykinesia, rigidity and tremor

and Q.L

[DOI] [PubMed] [Google Scholar] 255.Monteiro R., Azevedo I

Piper methysticum G

Intracerebral inoculation of pathological -synuclein initiates a rapidly progressive neurodegenerative -synucleinopathy in mice

While other flavonoids like resveratrol may impose hepatic or renal burden at high doses, curcumin has a well-established safety profile at appropriate dosages (Pourbagher-Shahri et al., 2021)
