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Similarly, the herbal formulation Jinlida granule has been found to reduce the expression of NLRP3, caspase-1, IL-1, and IL-18 in HFD-induced mouse livers as well as FFA-induced HepG2 cells, demonstrating its potential to alleviate liver injury and exert a protective effect against NAFLD by reducing hepatocyte pyroptosis [97]

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10.1155/2013/587140 56 HirschfieldG

Crossing the blood-brain barrier: advances in nanoparticle technology for drug delivery in neuro-oncology

Whether these effects arise directly from GLP-1 receptor activation in testicular tissue or indirectly through systemic metabolic improvement remains unresolved