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In addition, castration also increased the expression of ROS-production related genes such as Nox1 and GP91PHOX (the catalytic subunit of Nox2) and decreased the levels of antioxidant enzymes such as superoxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1), thioredoxin, and peroxiredoxin 5 in the prostate alveolar epithelium of rats (125)

10 Although this treatment led to ~80% SVR in patients infected with HCV genotype 2 or 3, it only led to ~50% SVR in patients infected with HCV genotype 1 and those with high viral loads

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Adenosine, caffeine, and sleepwake regulation: State of the science and perspectives

doi:10.1093/jsxmed/qdaf068.108 King SH, Mayorov AV, Balse-Srinivasan P, Hruby VJ, Vanderah TW, Wessells H

Journal of the American Oil Chemists Society