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Matrix metalloproteinase 2 and 9 expression MMPs are zinc- and calcium-dependent proteases that promove not only the disruption and remodeling of structural barriers [87-89] but also a response to signaling molecules, acting as ligand for cellular adhesion receptors [90-92]

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In addition, consensus sequences for each GT obtained using Roche-NGS in both single- and mixed-GT cohorts, including consensus sequence of each HCV co-infection, were built

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Resulting stacks were further processed using the sum-slice projection function of Fiji ( For in vivo quantification single plane images were used