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it is characterized by the activation of caspase-1, caspase-8, and caspase-3 and the phosphorylation of MLKL, which are fundamental molecular events of pyroptosis, apoptosis, and necroptosis (Kuriakose et al., 2016)

& Kregel, K

doi: 10.1021/ja502754f 159 WangJWangYLiZZhanPBaiRPannecouqueCet al

However, the study participants were not diagnosed with MDD [83]

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The clustered DNA double-strand breaks induced by combined irradiation result in the accumulation of double-stranded DNA fragments in the cytoplasm, activating the cGAS-STING-mediated cytosolic DNA sensing pathway, which further promotes NCOA4-FTH1 axis-driven ferritinophagy, ultimately leading to iron-dependent cell death (154)