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doi: 10.1007/s12640-015-9550-z 90

Mitochondrial and metabolic dysfunction in Friedreich ataxia: update on pathophysiological relevance and clinical interventions

So if something goes wrong and the GSSG accumulates, it inhibits an enzyme that relies on the correct oxidation of the ER environment to operate a protein quality control system. Moreover, they discovered, when misfolded proteins dont pass quality control, they wont get exported, so they too pile up in the ER
Tang, R.-H

10.1152/physrev.00024.2003 13 BachmannS.BellM.KlimekJ.ZempelH

Administration Options: Research protocols may involve subcutaneous injection or intranasal delivery , depending on the intended experimental framework
