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While the males fed Org-Se, the increases were 14.01%, 20.01%, and 26.09%, respectively

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Mechanistically, L2HG acts as a metabolic-epigenetic regulator that inhibits 2-oxoglutarate-dependent dioxygenases, induces histone hypermethylation, and remodels chromatin accessibility to activate an ATF3-dependent transcriptional program