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These combination strategies represent a multifaceted approach to addressing the complex pathophysiology of severe asthma

Animal Model:LPS (0.5 mg/kg)-induced acute lung injury mice model [3] Dosage:15 and 30 mg/kg Administration:i.p., twice a day for 5 days Result:Reduced leukocyte infiltration

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Kobayashi M, et al

LC/MS/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation

Nat Methods (2012) 9(7):6715.10.1038/nmeth.2089 47 CuencaAGDelanoMJKelly-ScumpiaKMMoldawerLLEfronPA

However, DNA methylation can be reversible, mediated by the ten-eleven translocation (TET) family of DNA dioxygenases that progressively oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (147151)