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72 found that patients with skeletal disease tended to have very subnormal bone ALP activity, and that PLP levels were increased in HPP and were related to disease severity

Shen JW, Yu HY, Ruan Y, et al

The primary damaging effect is associated with a profound loss of astrocytic glutamate clearance, leading to excitotoxicity 246,247

Its aggravating and anxiety producing, and its associated with dizziness at times

In neuroblastoma cells, miR-153, miR-27a, miR142-5p, and miR-144 directly target 3-untranslated region (UTR) of NFE2L2 and changes in these miRNAs either individually or as a group could result in inefficient transactivating ability of NRF2 [45]
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