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You can use an ice pack if you want, but you may have a hard time getting younger children to sit still with the cold pack on their skin

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No dose-escalation or maximum tolerated dose studies have been conducted, limiting understanding of safety at higher doses

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The transcriptional profile of the skin microbiota in HL414 was different from other healthy subjects after vitamin B12 supplementation To understand why subject HL414, not others in our healthy cohort, developed acne after vitamin B12 supplementation, we further investigated the specific bacterial transcriptional changes in HL414 compared to the other subjects 14 days after vitamin B12 supplementation