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Most of the lead compounds (curcumin, resveratrol, EGCG) are affected by their poor oral bioavailability, rapid metabolism (glucuronidation/sulfation), low stability, or low tissue penetration properties, which make it challenging to attain and maintain the cellular concentrations utilized in vitro [121, 392]

However, edaravone causes hypersensitivity and allergic reactions in some patients and may be effective in less than 5% of the ALS population [Writing Group

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[DOI] [PubMed] [Google Scholar] Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, et al

GO was modified with five derivatives, among which pyridoxine-modified GO containing 2.32% pyridinic nitrogen showed the best performance