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Therefore, we will introduce the mechanism of these drugs and discuss their current therapeutic application progress in the following sections (Table 1)

Nevertheless, before these technologies may be clinically translated, there are a number of challenges that need to be conquered

In Cluster 1, which consisted of patients with the most symptoms and comorbidities, IgG (73.3%) and manual lymphatic drainage (73.9%) had the highest positive response rates, together with Fluids/Electrolytes (73.4%) and pacing (67.5%)

(doi: 10.3892/mmr.2019.10374)

Do B12 shots help with energy and fatigue

Regarding management, there are several clinical trials that aim to elucidate optimal treatment strategies for steroid-refractory irAEs