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Description
Performed the experiments: SMN INR

Importantly, the additive lifespan extension effect observed when administering both metformin and phenformin together is completely dependent on the genetic factors AAK-2/AMPK, SKN-1/Nrf2, and mitochondrial complex I (Figure 2C), indicating that irrespective of the mechanism of the additivity, the lifespan extending effect of co-administered metformin and phenformin converges on the same set of downstream effectors

**Based on a 12-week clinical study of 28 participants ages 3565 with once-daily application of IMAGE MD restoring power-C serum and DAILY PREVENTION advanced smartblend mineral moisturizer SPF 75

Am J Physiol Endocrinol Metab (1999) 276(6 39-6):E1146E1170

Supports Cellular Energy Metabolism

(PubMed) Khalili M, Azimi A, Izadi V, et al
