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2.1.1 Heavy metal elements Heavy metals and their derivatives pose significant reproductive health risks due to their propensity for bioaccumulation and cellular disruption

The compound has better oral bioavailability than many peptides due to its small molecular weight (177.21 Da)

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Tirzepatide favors the GLP-1R over the GIPR at mouse incretin receptors, whereas the opposite has been reported for the relative potency in human incretin receptors, for which tirzepatide activity is tilted towards the GIPR 5,16